A home health nurse provides instructions to the spouse of a client taking tacrine hydrochloride for the management of moderate dementia associated with Alzheimer’s disease. Which information should the nurse provide to the spouse?

• “Administer the medication with food.”
• “If a dose is missed, double up on the next dose.”
• “If flu-like symptoms occur, notify the healthcare provider immediately.”
• “If you see a change in the color of the skin or stool, notify the healthcare provider.”